Bob posted a very cool video of Junior Brown, which got me thinking about other amazing guitar players.
Eric Johnson. The part you'll recognize starts about 2 minutes in.
Chet Atkins and Les Paul. The first two and a half minutes are them goofing on each other but then it's, well - it's Chet Atkins and Les Paul.
B.B. King and Eric Clapton.
Same instrument, different interpretations.
OK, Junior Brown, too, on his own design guitar:
I'd put in some Stevie Ray Vaughn and Otis Rush, too, but that much awesome compressed into a single blog post might rupture the fabric of Space-Time.