Also, keep in mind that anyone who cares about security and observes Safe Computing rules is by definition not the malware-writers' preferred target. Remember the lion and the antelope. Lions don't bother chasing fast antelope, they target the slower ones. Malware-writers don't bother targeting you or me; they go after the poor schlemiel who thinks the one-year subscription to Norton Antivirus that came with their new PC two years ago is enough to protect them forevermore.Darn tootin'. Remember you don't have to outrun the lion. You just have to outrun that doofus who thinks than an expired Norton Internet Security Suite will save his sorry butt.
Stick a router between your computer and your cablemodem, run a software firewall on every PC, run regular sweeps with a good antivirus product like MalwareBytes, never run an unsecured webserver or any program with server capabilities, and be careful what you download and from where. I can't guarantee that you'll never be infected if you do these things, but I can tell you that these measures will cut your odds of infection by 95%. Or better.
The only thing I'd add to his excellent advice is to back up your data early and often. Remember that data backups are like concealed carry firearms, that something can go wrong and that will happen at the worst possible moment. Two is one, and one is none.