Bono, frontman for the Band U2, took a very bad fall off a bicycle in November. He is 54 and his injuries included fractures to his left eye socket, shoulder blade and left elbow. The elbow had to be replaced.
He is, in his own words, unable to move around physically since the accident and thinks it unlikely that he will ever play a guitar again.
Whatever you think of his music and his politics, his life has been permanently altered by one moment.