Here's a PDF file with load data and shooting results from CastPics.net.
Since the standard bullet for .45 ACP is 230 grains, heavy bullets could be anything above that. I think of 246 gr. Elmer Keith bullets but there are heavier. I have the mold for the 452424 and have loaded both in .45 ACP and .45 Colt with that.
As he mentions, the larger bullets are seated deeper in the .45 ACP cases and that changes the pressure for any given powder load. The data in this article is for loads for modern revolvers like the Ruger Blackhawk.Compare your data with several sources and work up your loads from a safe minimum.
This was taken last Sunday at the range. I was shooting some 200 gr. button nose bullets that would not cycle in my 1911.